Symbol
Name
ID

Nr1h4
nuclear receptor subfamily 1, group H, member 4
MGI:1352464

Phenotype annotations related to liver/biliary system

Darker colors indicate more annotations

Human Phenotypes	Cirrhosis	Micronodular cirrhosis	Subacute progressive viral hepatitis	Jaundice	Hepatocellular carcinoma
Disease(s) Associated with NR1H4	Cirrhosis	Micronodular cirrhosis	Subacute progressive viral hepatitis	Jaundice	Hepatocellular carcinoma
hepatocellular carcinoma
progressive familial intrahepatic cholestasis 5

Mouse Phenotypes

abnormal liver sinusoid morphology

increased hepatocyte apoptosis

focal hepatic necrosis

increased hepatocyte proliferation

enlarged gallbladder

enlarged liver

increased liver weight

increased liver cholesterol level

increased liver triglyceride level

liver inflammation

abnormal liver morphology

abnormal hepatocyte morphology

abnormal liver perisinusoidal space morphology

hepatic steatosis

liver degeneration

increased liver tumor incidence

increased hepatocellular carcinoma incidence

increased liver adenoma incidence

abnormal bile secretion

abnormal bile composition

abnormal liver physiology

jaundice

Availability

Mouse Genotype

Nr1h4^tm1.1Mbj/Nr1h4^tm1.1Mbj

Nr1h4^tm1.2Auw/Nr1h4^tm1.2Auw

Nr1h4^tm1Gonz/Nr1h4^tm1Gonz

Nr1h4^tm1Kok/Nr1h4^tm1Kok

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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